In a historic stride toward eliminating HIV, Zambia has successfully expanded its pioneering rollout of Lenacapavir, a groundbreaking long-acting injectable pre-exposure prophylaxis (PrEP) drug, across 106 public health clinics spanning 13 high-burden districts.
The massive scale-up marks a significant shift away from the traditional daily oral PrEP pills, which health workers say suffer from low adherence rates due to pill fatigue and deep-seated societal stigma.
Lenacapavir, which requires only two injections per year, offers an invisible, highly effective shield for individuals who are HIV-negative but face a high risk of exposure.
The expansion has sparked widespread optimism among health advocates who believe the discreet nature of the injection will drastically improve uptake among vulnerable populations, particularly young women and adolescent girls.
“For years, our biggest hurdle in HIV prevention has not been the lack of medicine, but the difficulty of keeping people on daily treatments,” explained Ministry of Health spokesperson Dr Mwansa Kato.
“With Lenacapavir, an individual only needs to think about their HIV prevention strategy twice a year. It completely shifts the power back into the hands of the citizen, offering total confidentiality and convenience.”
At the Chawama Level One Hospital in Lusaka, long queues of eager citizens registered for the new program yesterday, signaling high community acceptance.
Early feedback from beneficiaries indicates that the fear of friends or family members discovering a daily pill bottle had previously deterred them from seeking prevention.
International health partners have lauded Zambia’s aggressive implementation strategy, noting that the country is currently leading the sub-Saharan region in making this advanced biomedical prevention tool accessible within the public sector.
“We are rewriting the narrative of HIV response in Africa,” Dr Kato emphasized during an inspection of the distribution chain.
“By integrating Lenacapavir into 106 rural and urban public clinics simultaneously, we are ensuring that cutting-edge science is not reserved just for the affluent, but is a fundamental right for every Zambian.”
Health workers are currently undergoing specialised training to manage the rollout, with the government hoping to expand the service to all 10 provinces by the end of next year.




